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Bispecific fusion protein is a major bispecific antibody format and it is generated by linking other proteins to the antibody or antibody fragments to add more functionality or specificity. The source of antibody fragments can be derived from scFv or monospecific Fab dimer. The linker protein can be specific receptors of lymph cells (such as T cell, B cell or macrophage); a second Fab molecule; or a strong and specific ligand of a receptor on tumor cells. Besides that, human serum albumin or albumin binding proteins can also be fused with antibody fragments to extend their serum half-life in vivo. Some of bispecific fusion proteins has been explored as a pre-targeting strategy for imaging and radioimmunotherapy. Compared with BsAb conjugates, the bispecific fusion proteins are engineered and generated by recombinant expression.