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Background

In vivo test refers to the experimentation within the whole and living organisms, such as mouse and rat. In vivo studies include both animal studies and clinical trials. Since in vivo studies has the potential to provide the conclusive insights about the safety assessment of Protein Degraders, they are critically instructive to explore the most potential Protein Degraders which can be pushed into clinical trials. Creative Biolabs is proficient at in vivo animal studies to facilitate the Protein Degraders discovery and development projects prior to clinical stages.

Introduction of Protein Degraders In Vivo Animal Test Assays

Protein Degraders is small molecule which consists of a target protein ligand, an E3 ligase ligand, and a linker. It can be a potential drug because of the degradation function targeted disease-causing proteins. For drug discovery and development process, in vivo animal tests are very important and determinant if the candidate Protein Degraders can be investigated for clinical trials. In addition, the results of in vivo animal tests can be used to guide the lead optimization of Protein Degraders to ensure low toxicity and better ADME properties. In Creative Biolabs, both toxicity test and ADME test are available for Protein Degraders in vivo services.