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CDC-Enhanced Antibody Services – Creative Biolabs

Creative Biolabs also provides antibody engineering services to enhance complement-dependent cytotoxicity (CDC). Their CDC⁺ antibody engineering platform focuses on increasing C1q binding via Fc region modifications and complement control protein displacement technologies.

Key Features and Services:

  • Fc Engineering (CH2 Mutations): Specific substitutions (e.g., S267E) to boost C1q interaction, improving CDC activity up to 47-fold.

  • Crea-Tag™ Technology: A novel tag fused to antibodies to displace complement factor H, enhancing complement activation on target cells.

  • Dual-Enhanced Antibodies (ADCC+CDC): Combined Fc and glycan engineering to achieve both ADCC and CDC improvement.

  • Functional CDC Assays: C1q binding, complement cascade activation, cell lysis verification.

  • Biobetter Antibody Products: CDC-enhanced antibodies targeting CD5, BAFF, CA125, and more for research use.

  • Production and Development: Antibody expression in mammalian (CHO, HEK293) or insect cells, purification, QC, and process development under GMP-ready standards.

These services are ideal for researchers targeting diseases where CDC is a key mechanism, such as B-cell malignancies and autoimmune diseases.

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