Golf

EPRS is a bifunctional enzyme that mainly exists in the cytoplasm of eukaryotes. This enzyme can not only catalyze the synthesis of glutamyl-trNA but also participate in the γ -interferon mediated translation inhibition pathway as a component of the multi-protein complex, playing a dual role in protein synthesis and immune regulation. Mammalian cells rely on EPRS to precisely regulate protein translation, especially selectively inhibiting the translation of specific mRNAs when responding to inflammatory reactions. Initially identified as a member of the aminoacyl-trNA synthase family in 1978, EPRS has become one of the most deeply studied enzymes in this family due to its unique bifunctional characteristics. The analysis of its crystal structure provides an important basis for understanding the mechanism of enzymatic reactions.

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