kits.traumatologi.no

Broad Neutralizing sdAb
As the harmful toxin and virus outbreak poses an enormous global risk, a more potent and broad neutralizing antibody vaccine is a certainly valuable tool for future consideration, especially as conserved epitopes are identified for cross-protective antibody responses against future pandemics. Due to common variations in the protein domains, some neutralizing sdAbs are often virus-specific and neutralize related viruses poorly. However, for efficient prevention of viral/toxin infections and cross-protection, simultaneous targeting of multiple epitopes or binding a conserved core structure is a powerful strategy. The generated broad neutralizing sdAb opens possibilities to achieve “best-in-class” and broader neutralization capacity for cross-neutralizing related toxins and viruses. Broad neutralizing sdAb can alter the course of infection in the infected host supporting toxin or virus clearance and protect an uninfected host that is exposed to a broad panel from different subtypes of virus or related toxin. Hence, these best broad neutralizing sdAb candidates may be served as useful therapeutics to offer broad protection against many variants and subtypes of viruses or toxins and to prevent and/or treat related diseases.